Pierce Brosnan's daughter Charlotte has died of ovarian cancer at the age of 41 after a three-year battle with the disease.
Her mother, Cassandra Harris, died from the same type of cancer in 1991 while she was married to Brosnan.
Harris also lost her own mother to ovarian cancer when she was a teenager.
In a statement to People magazine, Brosnan said: "On June 28 at 2pm my darling daughter Charlotte Emily passed on to eternal life, having succumbed to ovarian cancer.
"She was surrounded by her husband Alex, children Isabella and Lucas, and brothers Christopher and Sean.
"Charlotte fought her cancer with grace and humanity, courage and dignity. Our hearts are heavy with the loss of our beautiful dear girl.
"We pray for her and that the cure for this wretched disease will be close at hand soon.
"We thank everyone for their heartfelt condolences."
The actor adopted Charlotte and her brother Christopher in the 1980s after the death of their father and the children took Brosnan's name.
He also had another son, Sean, with Cassandra Harris in 1983.
The Irish-born actor, who starred in four James Bond films, married his second wife Keely Shaye in 2001 and the couple have two children together.
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